Anti-Pin1 Rabbit antibody

Cat.#: 168727

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Product Information

  • Product Name
    Anti-Pin1 Rabbit antibody
  • Documents
  • Description
    Pin1 Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC, IP
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    DOD; UBL5 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of mouse Pin1
  • Clonality
    Monoclonal
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    IHC: 1/20

    ICC/IF: 1/20

    FC: 1/100

    IP: 1/20

  • Validations

    Western blot detection of Pin1 in Jurkat,Rat Brain,C6,CHO-K1,Hela cell lysates using Pin1 Rabbit mAb(1:1000 diluted).Predicted band size:18kDa.Observed band size:18kDa.

    Western blot detection of Pin1 in Jurkat,Rat Brain,C6,CHO-K1,Hela cell lysates using Pin1 Rabbit mAb(1:1000 diluted).Predicted band size:18kDa.Observed band size:18kDa.

  • Background
    Swiss-Prot Acc.Q13526.Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"