Anti-PACT (phospho KR activating protein)/PRKRA Rabbit antibody
PACT (phospho KR activating protein)/PRKRA Rabbit monoclonal antibody
Human, Mouse, Rat
RAX; PACT; DYT16; HSD14 antibody
Antigen: A synthetic peptide of of human PACT (phospho KR activating protein)/PRKRA
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
Western blot detection of PACT (phospho KR activating protein)/PRKRA in C6,3T3,Hela cell lysates using PACT (phospho KR activating protein)/PRKRA Rabbit mAb(1:1000 diluted).Predicted band size:34kDa.Observed band size:34kDa.
Swiss-Prot Acc.O75569.Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner .
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