Anti-MSH6 (3E1) Mouse antibody

Cat.#: 168530

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Product Information

  • Product Name
    Anti-MSH6 (3E1) Mouse antibody
  • Documents
  • Description
    MSH6 (3E1) Mouse monoclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC
  • Species reactivity
    Human
  • Isotype
    IgG2a
  • Preparation
    Antigen: Purified recombinant fragment of human MSH6 expressed in E. Coli.
  • Clonality
    Monoclonal
  • Formulation
    Ascitic fluid containing 0.03% sodium azide.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500 - 1/2000

    IHC: 1/200 - 1/1000

    ICC: 1/200 - 1/1000

    FC: 1/200 - 1/400

    ELISA: 1/10000

  • Validations

    Western blot detection of MSH6 in 293 and HCT116 cell lysates using MSH6 mouse mAb (1:300-1:500 diluted).Predicted band size:160KDa.Observed band size:160KDa.

    Western blot detection of MSH6 in 293 and HCT116 cell lysates using MSH6 mouse mAb (1:300-1:500 diluted).Predicted band size:160KDa.Observed band size:160KDa.

    Immunocytochemistry staining of HeLa cells using MSH6 mouse mAb (dilution 1:100).

    Immunocytochemistry staining of HeLa cells using MSH6 mouse mAb (dilution 1:100).

  • Background
    Swiss-Prot Acc.P52701.This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"