Anti-MSH6 (3E1) Mouse antibody
MSH6 (3E1) Mouse monoclonal antibody
WB, IHC-P, ICC/IF, FC
Antigen: Purified recombinant fragment of human MSH6 expressed in E. Coli.
Ascitic fluid containing 0.03% sodium azide.
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
WB: 1/500 - 1/2000
IHC: 1/200 - 1/1000
ICC: 1/200 - 1/1000
FC: 1/200 - 1/400
Western blot detection of MSH6 in 293 and HCT116 cell lysates using MSH6 mouse mAb (1:300-1:500 diluted).Predicted band size:160KDa.Observed band size:160KDa.
Immunocytochemistry staining of HeLa cells using MSH6 mouse mAb (dilution 1:100).
Swiss-Prot Acc.P52701.This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.
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