Anti-MMP2 antibody

Anti-MMP2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Mouse MMP2

WB, IP

Mouse MMP2 / MMP-2 / CLG4A

CLG4 antibody; MONA antibody; CLG4A antibody; MMP-2 antibody; TBE-1 antibody; MMP-II antibody; GelA antibody; Clg4a antibody; MMP-2 antibody; CLG4 antibody; Clg4a antibody; CLG4A antibody; GelA antibody; Mmp2 antibody; MMP2 antibody; MMP-2 antibody; MMP-2 antibody; MMP-II antibody; MONA antibody; TBE-1 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Mouse MMP2 / MMP-2 / CLG4A . MMP2 / MMP-2 / CLG4A specific IgG was purified by Mouse MMP2 / MMP-2 / CLG4A affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.