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  • Anti-MLH1 Rabbit antibody

Anti-MLH1 Rabbit antibody

Cat.#: 167794

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Product Information

  • Product Name
    Anti-MLH1 Rabbit antibody
  • Documents
  • Description
    MLH1 Rabbit monoclonal antibody
  • Tested applications
    IHC-P, ICC/IF, FC
  • Species reactivity
    Human
  • Isotype
    IgG
  • Preparation
    Antigen: Recombinant protein of human MLH1
  • Clonality
    Monoclonal antibody
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    IHC: 1/50

    ICC/IF: 1/50

    FC: 1/20

  • Validations

    Western blot detection of MLH1 in Hela,A549,HL-60,U2OS cell lysates using MLH1 Rabbit mAb(1:1000 diluted).Predicted band size:85kDa.Observed band size:85kDa.

    Western blot detection of MLH1 in Hela,A549,HL-60,U2OS cell lysates using MLH1 Rabbit mAb(1:1000 diluted).Predicted band size:85kDa.Observed band size:85kDa.

  • Background
    The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"