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  • Anti-Ku80 (5C5) Mouse antibody
  • Anti-Ku80 (5C5) Mouse antibody
  • Anti-Ku80 (5C5) Mouse antibody

Anti-Ku80 (5C5) Mouse antibody

Cat.#: 168487

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Product Information

  • Product Name
    Anti-Ku80 (5C5) Mouse antibody
  • Documents
  • Description
    Ku80 (5C5) Mouse monoclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC, IP
  • Species reactivity
    Human, Mouse
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Purified recombinant fragment of human XRCC5 expressed in E. Coli.
  • Clonality
    Monoclonal antibody
  • Formulation
    Ascitic fluid containing 0.03% sodium azide.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500 - 1/2000

    IHC: 1/200 - 1/1000

    ICC: 1/200 - 1/1000

    FC: 1/200 - 1/400

    ELISA: 1/10000

  • Validations

    Western blot detection of Ku80 in A549,MCF7 and Hela cell lysates using Ku80 mouse mAb (dilution 1:500).Predicted band size:86KDa.Observed band size:86KDa.

    Western blot detection of Ku80 in A549,MCF7 and Hela cell lysates using Ku80 mouse mAb (dilution 1:500).Predicted band size:86KDa.Observed band size:86KDa.

    Immunoprecipitation analysis of Hela cell lysates using XRCC5 antibody.

    Immunoprecipitation analysis of Hela cell lysates using XRCC5 antibody.

    Immunocytochemistry of HeLa cells using Ku80 mouse mAb (dilution 1:100).

    Immunocytochemistry of HeLa cells using Ku80 mouse mAb (dilution 1:100).

  • Background
    Swiss-Prot Acc.P13010.The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"