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Product Name
Anti-HPGD/15-PGDH antibody
- Documents
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Description
Rabbit monoclonal to HPGD/15-PGDH
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Tested applications
WB, IP
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Species reactivity
Mouse HPGD / 15-PGDH
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Alternative names
15-PGDH antibody; 15-PGDH antibody; AV026552 antibody; Hpgd antibody; HPGD antibody; MGC14001 antibody; PGDH1 antibody; SDR36C1 antibody; PGDH antibody; PGDH antibody; PGDH1 antibody; PHOAR1 antibody; 15-PGDH antibody; SDR36C1 antibody; 15-PGDH antibody; AV026552 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse HPGD / 15-PGDH (rM HPGD / 15-PGDH; Q8VCC1; Met1-Ser269).
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 2-10 μg/mL
IP: 1-4 μg/mg of lysate
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Validations
HPGD / 15-PGDH Antibody, Rabbit MAb, Western blot
HPGD / 15-PGDH Antibody, Rabbit MAb, Immunoprecipitation
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Background
Mouse 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) , cranioosteoarthropathy (COA), and isolated congenital nail clubbing.
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References
- Patel, FA. et al., 2003, J. Clin. Endocrinol. Metab. 88: 2922-33.
- McKeown KJ, et al.,2003, J. Clin. Endocrinol. Metab. 88 (4): 1737-41.
- Yan, M. et al., 2004, Proc. Natl. Acad. Sci. USA. 101: 17468-73.
- Tariq, M. et al., 2009, J Med Genet. 46 (1): 14-20.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"