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Product Name
Human HPGD/15-PGDH (His Tag) recombinant protein
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Description
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
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Protein name
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
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Protein short names
PGDH1; PHOAR1; PGDH; AV026552; MGC14001; HPGD; 15-PGDH; SDR36C1
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Uniprot ID
P15428
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Gene Name
HPGD; PGDH1; SDR36C1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human HPGD (NP_000851.2) (Met 1-Gln 266) was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human HPGD comprises 272 amino acids and has a predicted molecular mass of 29.7 kDa. It migrates as an approximately 27 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 92 % as determined by SDS-PAGE
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Activity
Measure by the production of NADH during the oxidation of PGF2α. The specific activity is >1,500 pmoles/min/μg.
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Validations
Human HPGD / 15-PGDH Protein (His Tag) SDS-PAGE
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