Anti-HDAC2 (2D9) Mouse antibody

Anti-HDAC2 (2D9) Mouse antibody

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• Material Safety Data Sheets (MSDS)

HDAC2 (2D9) Mouse monoclonal antibody

WB, ICC/IF

Human, Mouse, Rat, Monkey

D10Wsu179e ;HD 2 ;HD2 ;HDAC 2 ;Hdac2 ;HDAC2_HUMAN ;Histone deacetylase 2 (HD2) ;Histone deacetylase 2 ;OTTHUMP00000017046 ;OTTHUMP00000227077 ;OTTHUMP00000227078 ;RPD3 ;transcriptional regulator homolog RPD3 ;YAF1 ;YY1 associated factor 1 ;YY1 transcription factor binding protein ;Yy1bp. antibody

Mouse IgG2b

Antigen: Purified recombinant human HDAC2 protein fragments expressed in E.coli.

Monoclonal

PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.Q92769.Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.