Anti-HDAC2 (2D9) Mouse antibody

Cat.#: 168322

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Product Information

  • Product Name
    Anti-HDAC2 (2D9) Mouse antibody
  • Documents
  • Description
    HDAC2 (2D9) Mouse monoclonal antibody
  • Tested applications
    WB, ICC/IF
  • Species reactivity
    Human, Mouse, Rat, Monkey
  • Alternative names
    D10Wsu179e ;HD 2 ;HD2 ;HDAC 2 ;Hdac2 ;HDAC2_HUMAN ;Histone deacetylase 2 (HD2) ;Histone deacetylase 2 ;OTTHUMP00000017046 ;OTTHUMP00000227077 ;OTTHUMP00000227078 ;RPD3 ;transcriptional regulator homolog RPD3 ;YAF1 ;YY1 associated factor 1 ;YY1 transcription factor binding protein ;Yy1bp. antibody
  • Isotype
    Mouse IgG2b
  • Preparation
    Antigen: Purified recombinant human HDAC2 protein fragments expressed in E.coli.
  • Clonality
    Monoclonal
  • Formulation
    PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

  • Validations

    Western blot detection of HDAC2 in THP-1,SHSY-5Y,K562,COS7,C6,3T3 and Hela cell lysates using HDAC2 mouse mAb(dilution 1:1000).Predicted band size:60kDa.Observed band size:60kDa.

    Western blot detection of HDAC2 in THP-1,SHSY-5Y,K562,COS7,C6,3T3 and Hela cell lysates using HDAC2 mouse mAb(dilution 1:1000).Predicted band size:60kDa.Observed band size:60kDa.

  • Background
    Swiss-Prot Acc.Q92769.Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"