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Product Name
Anti-Galectin 3 Rabbit antibody
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Description
Galectin 3 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, FC
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Species reactivity
Human, Mouse, Rat
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Alternative names
L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Galectin 3
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/5000
IHC: 1/200
FC: 1/200
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Validations
Immunohistochemistry of Galectin 3 in paraffin-embedded Human colon cancer tissue using Galectin 3 Rabbit pAb at dilution 1/50
Western blot detection of Galectin 3 in 3T3,Hela cell lysates using Galectin 3 Rabbit pAb(1:1000 diluted).Predicted band size:26kDa.Observed band size:28kDa.
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Background
Swiss-Prot Acc.P17931.Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis . In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"