Cart 2
  • Anti-FOXO1 Rabbit antibody
  • Anti-FOXO1 Rabbit antibody
  • Anti-FOXO1 Rabbit antibody

Anti-FOXO1 Rabbit antibody

Cat.#: 167386

Size:

Special Price 441.3 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Anti-FOXO1 Rabbit antibody
  • Documents
  • Description
    FOXO1 Rabbit polyclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    FKH 1;FKH1;FKH1;FKHR;FKHR;Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma);Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma);Forkhead box O1;Forkhead box protein O1; Forkhead box protein O1A;Forkhead in rhabdomyosarcoma;Forkhead antibody; Drosophila antibody; homolog of antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human FOXO1A
  • Clonality
    Polyclonal antibody
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000-1/5000

    IHC: 1/50-1/200

    ICC/IF: 1/20-1/50

    FC: 1/20

  • Validations

    Immunocytochemistry of FOXO1A(green) in Hela cells using FOXO1A Rabbit pAb at dilution 1/50, and DAPI(blue)

    Immunocytochemistry of FOXO1A(green) in Hela cells using FOXO1A Rabbit pAb at dilution 1/50, and DAPI(blue)

    Immunohistochemistry of FOXO1A in paraffin-embedded Human tonsil using FOXO1A Rabbit pAb at dilution 1/100

    Immunohistochemistry of FOXO1A in paraffin-embedded Human tonsil using FOXO1A Rabbit pAb at dilution 1/100

    Western blot detection of FOXO1A in HepG2 cell lysates using FOXO1A Rabbit pAb(1:1000 diluted).Predicted band size:70KDa.Observed band size:70KDa.

    Western blot detection of FOXO1A in HepG2 cell lysates using FOXO1A Rabbit pAb(1:1000 diluted).Predicted band size:70KDa.Observed band size:70KDa.

  • Background
    Swiss-Prot Acc.Q12778.Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling .
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"