Anti-FGFR1/CD331 antibody

Anti-FGFR1/CD331 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse monoclonal to FGFR1/CD331

IHC-P

Human FGFR1 / CD331
No cross-reactivity in ELISA with Human FGFR2

AW208770 antibody; BFGFR antibody; CD331 antibody; CEK antibody; FGFBR antibody; FGFR1 antibody; Fgfr1 antibody; Fgfr-1 antibody; FLG antibody; FLG antibody; CEK antibody; FLG antibody; FLJ99988 antibody; HH2 antibody; OGD antibody; FLT2 antibody; KAL2 antibody; BFGFR antibody; CD331 antibody; FGFBR antibody; FLT-2 antibody; FLT2 antibody; HBGFR antibody; N-SAM antibody; FGFR-1 antibody; HRTFDS antibody; bFGF-R-1 antibody; FLG antibody; MFR antibody; Eask antibody; Hspy antibody; Flt-2 antibody; Flt-2 antibody; c-fgr antibody; Fgfr-1 antibody; AW208770 antibody; bFGF-R-1 antibody; HBGFR antibody; KAL2 antibody; N-SAM antibody; OGD antibody

Mouse IgG2a

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human FGFR1 / CD331 (rh FGFR1 / CD331; NP_075594.1; Met1-Glu285). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ，idiopathic hypogonadotropic hypogonadism， Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.

• Schlessinger J, et al. (2000) Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell. 6(3):743-50.
• Dodé C, et al. (2007) Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis. Hum Mutat. 28(1): 97-8.
• Kim HG, et al. (2005) Hypogonadotropic hypogonadism and cleft lip and palate caused by a balanced translocation producing haploinsufficiency for FGFR1. J Med Genet. 42(8):666-72.