Anti-FGFR1 antibody

Anti-FGFR1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human FGFR1

IHC-P

Human FGFR1/CD331

AW208770 antibody; BFGFR antibody; CD331 antibody; CEK antibody; FGFBR antibody; FGFR1 antibody; Fgfr1 antibody; Fgfr-1 antibody; FLG antibody; FLG antibody; CEK antibody; FLG antibody; FLJ99988 antibody; HH2 antibody; OGD antibody; FLT2 antibody; KAL2 antibody; BFGFR antibody; CD331 antibody; FGFBR antibody; FLT-2 antibody; FLT2 antibody; HBGFR antibody; N-SAM antibody; FGFR-1 antibody; HRTFDS antibody; bFGF-R-1 antibody; FLG antibody; MFR antibody; Eask antibody; Hspy antibody; Flt-2 antibody; Flt-2 antibody; c-fgr antibody; Fgfr-1 antibody; AW208770 antibody; bFGF-R-1 antibody; HBGFR antibody; KAL2 antibody; N-SAM antibody; OGD antibody; Eask antibody; Hspy antibody; MFR antibody; bFGF-R-1 antibody; c-fgr antibody; FGFR-1 antibody; FLT-2 antibody; HH2 antibody; HRTFDS antibody; bFGF-R-1 antibody

Rabbit IgG

Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human FGFR1/CD331, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ，idiopathic hypogonadotropic hypogonadism， Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy