Anti-EPHB2 antibody

Anti-EPHB2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Monoclonal to Human EPHB2

FCM

Human EPHB2 / Hek5

Drt antibody; Erk antibody; Nuk antibody; Cek5 antibody; Hek5 antibody; Qek5 antibody; Sek3 antibody; ETECK antibody; Prkm5 antibody; Tyro5 antibody; DRT antibody; EK5 antibody; ERK antibody; CAPB antibody; Hek5 antibody; PCBC antibody; EPHT3 antibody; Tyro5 antibody; ERK antibody; ERK antibody; CAPB antibody; Cek5 antibody; Drt antibody; DRT antibody; Ephb2 antibody; EphB2 antibody; EPHT3 antibody; ETECK antibody; Hek5 antibody; Hek5 antibody; MGC87492 antibody; Nuk antibody; PCBC antibody; Prkm5 antibody; Qek5 antibody; RP23-426N4.7 antibody; Sek3 antibody; Tyro5 antibody; Tyro5 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human EPHB2 / Hek5 (rh EPHB2 / Hek5; NP_059145.2; Met1-Leu543) and conjugated with PE under optimum conditions, the unreacted PE was removed.

Monoclonal

Aqueous solution containing 0.5% BSA and 0.09% sodium azide

This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

FCM

Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

• Zisch AH, et al. (1998) Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene. 16 (20): 2657-70.
• Yu HH, et al. (2001) Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. Oncogene. 20 (30): 3995-4006.
• Zisch AH, et al. (2000) Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. Oncogene. 19 (2): 177-87.