Human EphB2/Eph Receptor B2 (His & Fc Tag) recombinant protein

Cat.#: 503991

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Product Information

  • Product Name
    Human EphB2/Eph Receptor B2 (His & Fc Tag) recombinant protein
  • Documents
  • Description
    Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.
  • Protein name
    Ephrin type-B receptor 2
  • Protein short names
    CAPB; DRT; ERK; SEK3; ETECK; NUK; EPHT3; QEK5; CEK5; PCBC; EPHB2; TYRO5; HEK5; RP23-426N4.7; EK5; PRKM5; MGC87492
  • Uniprot ID
    Q6NVW1
  • Gene Name
    EPHB2; DRT; EPHT3; EPTH3; ERK; HEK5; TYRO5
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Leu 543) of human EphB2 (NP_059145.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human EphB2/Fc is a disulfide-linked homodimer. The reduced monomer consists of 773 amino acids and has a predicted molecular mass of 86 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh EphB2/Fc monomer is approximately 90-100 kDa due to glycosylation.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to bind recombinant human EphrinB2 in a functional ELISA.
  • Validations

    Human EphB2 Protein (His & Fc Tag) SDS-PAGE

    Human EphB2 Protein (His & Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"