Anti-Cyclophilin F Rabbit antibody

Cat.#: 167377

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Product Information

  • Product Name
    Anti-Cyclophilin F Rabbit antibody
  • Documents
  • Description
    Cyclophilin F Rabbit polyclonal antibody
  • Tested applications
    WB, IHC-P, FC
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    CYP3; CypD; CyP-M; Cyp-D antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human Cyclophilin F
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000

    IHC: 1/500

    FC: 1/100

  • Validations

    Western blot detection of Cyclophilin F in K562,3T3,Hela cell lysates using Cyclophilin F Rabbit pAb(1:1000 diluted).Predicted band size:22kDa.Observed band size:18kDa.

    Western blot detection of Cyclophilin F in K562,3T3,Hela cell lysates using Cyclophilin F Rabbit pAb(1:1000 diluted).Predicted band size:22kDa.Observed band size:18kDa.

  • Background
    Swiss-Prot Acc.P30405.PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"