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Product Name
Anti-Cyclin H Rabbit antibody
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Description
Cyclin H Rabbit monoclonal antibody
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Tested applications
WB
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Species reactivity
Human, Mouse, Rat
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Alternative names
CAK; p34; p37; CycH antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Cyclin H
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Clonality
Monoclonal
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Formulation
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000-1/5000
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Validations
Western blot detection of Cyclin H in Jurkat cell lysates using Cyclin H Rabbit mAb(1:1000 diluted).Predicted band size:38kDa.Observed band size:36kDa.
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Background
Swiss-Prot Acc.P51946.Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"