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Product Name
Anti-CXCL5 antibody
- Documents
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Description
Rabbit polyclonal to CXCL5
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Tested applications
ELISA, IHC-P
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Species reactivity
Human CXCL5
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Alternative names
AMCF-II antibody; C-X-C motif chemokine 5 antibody; C-X-C motif chemokine 5 antibody; cytokine LIX antibody; ENA-78 antibody; ENA-78 antibody; ENA-78(1-78) antibody; epithelial-derived neutrophil activating protein 78 antibody; epithelial-derived neutrophil-activating peptide 78 antibody; GCP-2 antibody; granulocyte chemotactic protein-2 antibody; LIX antibody; member 15 antibody; member 5 antibody; member 5 (epithelial-derived neutrophil-activating peptide 78) antibody; neutrophil-activating peptide ENA-78 antibody; neutrophil-activating protein 78 antibody; SCYB5 antibody; Scyb5 antibody; Scyb6 antibody; small inducible cytokine B subfamily antibody; small inducible cytokine B5 antibody; small inducible cytokine subfamily B antibody; small-inducible cytokine B5 antibody; small inducible cytokine subfamily B (Cys-X-Cys) antibody; SCYB5 antibody; ENA-78 antibody; LIX antibody; GCP-2 antibody; Scyb5 antibody; Scyb6 antibody; ENA-78 antibody; AMCF-II antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human CXCL5 (rh CXCL5; P42830; Arg45-Asn114). CXCL5 specific IgG was purified by Human CXCL5 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA: 0.1-0.2 μg/ml
This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Human CXCL5.
IHC-P: 0.1-2 μg/mL
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Validations
CXCL5 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of human CXCL5 in human pancreatic carcinoma with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
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Background
CXCL5 is a small cytokine belonging to the CXC chemokine family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL5 is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. It also can be detected in eosinophils, and can be inhibited with the type II interferon. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which can be utilized to understand more about pain in other inflammatory conditions like arthritis and cystitis. It stimulates the chemotaxis of neutrophils possesses angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.
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References
- Dawes JM, et al. (2011) CXCL5 Mediates UVB Irradiation-Induced Pain. Sci Transl Med. 3(90): 90ra60.
- O'Donovan N, et al. (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84(1-2):39-42.
- Persson T, et al. (2003) Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils. Clin Exp Allergy. 33(4):531-7.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"