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Product Name
Anti-CREB (1E9) Mouse antibody
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Description
CREB (1E9) Mouse monoclonal antibody
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Tested applications
WB
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Species reactivity
Human, Rat
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Alternative names
Active transcription factor CREB; cAMP response element binding protein 1; cAMP response element binding protein; cAMP responsive element binding protein 1; cAMP-responsive element-binding protein 1; CREB; CREB-1; CREB1; CREB1_HUMAN; Cyclic AMP-responsive antibody
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Isotype
IgG1
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Preparation
Antigen: Purified recombinant human CREB protein fragments expressed in E.coli.
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Clonality
Monoclonal
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Formulation
Ascites containing with 0.03% Proclin300 and 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
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Validations
Western blot detection of CREB in Jurkat,A549,MCF7,C6 and Hela cell lysates using CREB mouse mAb(dilution 1:1000).Predicted band size:46kDa.Observed band size:43kDa.
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Background
Swiss-Prot Acc.P16220.This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"