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Product Name
Anti-CNDP2 antibody
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Description
Rabbit polyclonal to CNDP2
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Tested applications
ELISA, WB, IP
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Species reactivity
Mouse CNDP2
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Alternative names
0610010E05Rik antibody; C76600 antibody; Cn2 antibody; CN2 antibody; Cndp2 antibody; CNDP2 antibody; CPGL antibody; Dip-2 antibody; FLJ10830 antibody; HsT2298 antibody; Pep1 antibody; Pep-1 antibody; PEPA antibody; CN2 antibody; CPGL antibody; PEPA antibody; HsT2298 antibody; HEL-S-13 antibody; Cn2 antibody; Pep1 antibody; Dip-2 antibody; Pep-1 antibody; C76600 antibody; 0610010E05Rik antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Mouse CNDP2 (rM CNDP2; NP_075638.2; Met 1-Asn 475). CNDP2 specific IgG was purified by Mouse CNDP2 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-20 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CNDP2. The detection limit for Mouse CNDP2 is approximately 0.00245 ng/well.
IP: 1-4 μg/mg of lysate
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Background
Mouse cytosolic non-specific dipeptidase, also known as CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2 and CN2, is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 / CPGL is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 / CPGL hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. It may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Isoform 1 of CNDP2 / CPGL is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 of CNDP2 / CPGL is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 / CPGL is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis.
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References
- Bakker,SJ. et al., 2008, Diabetes 57 (12):e16; author reply e17.
- Wanic, K. et al., 2008, Diabetes 57 (9): 2547-51.
- McDonough,CW. et al., 2009, Hum Genet 126 (2): 265-75.
- Kaur,H. et al., 2009, J Biol Chem. 284 (21):14493-502.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"