Anti-CNDP2 antibody

Cat.#: 103586

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Product Information

  • Product Name
    Anti-CNDP2 antibody
  • Documents
  • Description
    Rabbit polyclonal to CNDP2
  • Tested applications
  • Species reactivity
    Mouse CNDP2
  • Alternative names
    0610010E05Rik antibody; C76600 antibody; Cn2 antibody; CN2 antibody; Cndp2 antibody; CNDP2 antibody; CPGL antibody; Dip-2 antibody; FLJ10830 antibody; HsT2298 antibody; Pep1 antibody; Pep-1 antibody; PEPA antibody; CN2 antibody; CPGL antibody; PEPA antibody; HsT2298 antibody; HEL-S-13 antibody; Cn2 antibody; Pep1 antibody; Dip-2 antibody; Pep-1 antibody; C76600 antibody; 0610010E05Rik antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse CNDP2 (rM CNDP2; NP_075638.2; Met 1-Asn 475). CNDP2 specific IgG was purified by Mouse CNDP2 affinity chromatography.
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 10-20 μg/mL

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CNDP2. The detection limit for Mouse CNDP2 is approximately 0.00245 ng/well.

    IP: 1-4 μg/mg of lysate

  • Validations

    CNDP2 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    CNDP2 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    CNDP2 Antibody, Rabbit PAb, Antigen Affinity Purified

    CNDP2 Antibody, Rabbit PAb, Antigen Affinity Purified

  • Background
    Mouse cytosolic non-specific dipeptidase, also known as CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2 and CN2, is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 / CPGL is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 / CPGL hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. It may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Isoform 1 of CNDP2 / CPGL is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 of CNDP2 / CPGL is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 / CPGL is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis.
  • References
    • Bakker,SJ. et al., 2008, Diabetes  57 (12):e16; author reply e17. 
    • Wanic, K. et al., 2008, Diabetes  57 (9): 2547-51.
    • McDonough,CW. et al., 2009, Hum Genet 126 (2): 265-75.
    • Kaur,H. et al., 2009, J Biol Chem. 284 (21):14493-502.