Anti-CKMT1 (1A6) Mouse antibody

Anti-CKMT1 (1A6) Mouse antibody

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CKMT1 (1A6) Mouse monoclonal antibody

WB

Human, Mouse

Acidic type mitochondrial creatine kinase;CKMT;CKMT1;CKMT1A;CKMT1B;Creatine kinase mitochondrial 1 ubiquitous;Creatine kinase U type antibody; mitochondrial;Creatine kinase ubiquitous mitochondrial;Creatine kinase antibody; mitochondrial 1 (ubiquitous);Creatine kinase antibody; mit antibody

Mouse IgG1

Antigen: Purified recombinant human CKMT1 protein fragments expressed in E.coli.

Monoclonal

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4 150 mM NaCl) with 0.02% sodium azide 50% glycerol

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.P12532.Creatine kinase MT is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Creatine kinase MT occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.