Anti-CD132 / IL2RG antibody

Anti-CD132 / IL2RG antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to CD132 / IL2RG

ELISA, WB

Mouse CD132 / IL2RG

gamma(c) antibody; gc antibody; Il2rg antibody; IL2RG antibody; Il2rg antibody; IMD4 antibody; RP23-440J15.2 antibody; [g]c antibody; SCIDX antibody; CD132 antibody; gamma(c) antibody; P64 antibody; CIDX antibody; IMD4 antibody; CD132 antibody; SCIDX antibody; IL-2RG antibody; SCIDX1 antibody; SCIDX1 antibody; GC antibody; Ab2-183 antibody; Cd132 antibody; CD132 antibody; CD132 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Mouse CD132 / IL2RG (rM CD132 / IL2RG; NP_038591.1; Met 1-Ala 263). CD132 / IL2RG specific IgG was purified by Mouse CD132 / IL2RG affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (XSCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

• Russell SM, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 262 (5141): 1880-3.
• Miyazaki T, et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 266 (5187): 1045-7.
• Takeshita T, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science. 257 (5068): 379-82.