Anti-CD132 / IL2RG antibody

Anti-CD132 / IL2RG antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to CD132 / IL2RG

FCM

Mouse CD132 / IL2RG

gamma(c) antibody; gc antibody; Il2rg antibody; IL2RG antibody; Il2rg antibody; IMD4 antibody; RP23-440J15.2 antibody; [g]c antibody; SCIDX antibody; CD132 antibody; gamma(c) antibody; P64 antibody; CIDX antibody; IMD4 antibody; CD132 antibody; SCIDX antibody; IL-2RG antibody; SCIDX1 antibody; SCIDX1 antibody; GC antibody; Ab2-183 antibody; Cd132 antibody; CD132 antibody; CD132 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD132 / IL2RG (rM CD132 / IL2RG; NP_038591.1; Met1-Ala263) and conjugated with PE under optimum conditions, the unreacted PE was removed.

Monoclonal

Aqueous solution containing 0.5% BSA and 0.09% sodium azide

This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

FCM

The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (XSCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

• Russell SM, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 262 (5141): 1880-3.
• Miyazaki T, et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 266 (5187): 1045-7.
• Takeshita T, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science. 257 (5068): 379-82.