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Anti-Caspase-1 Rabbit antibody

Cat.#: 168722

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Special Price 247.7 USD

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Product Information

  • Product Name
    Anti-Caspase-1 Rabbit antibody
  • Documents
  • Description
    Caspase-1 Rabbit monoclonal antibody
  • Tested applications
    WB, IP
  • Species reactivity
    Human
  • Alternative names
    ICE; P45; IL1BC antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human Caspase-1
  • Clonality
    Monoclonal
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    IP: 1/20

  • Validations

    Western blot detection of Caspase-1 in Hela cell lysates using Caspase-1 Rabbit mAb(1:500 diluted).Predicted band size:45kDa.Observed band size:45,20kDa.

    Western blot detection of Caspase-1 in Hela cell lysates using Caspase-1 Rabbit mAb(1:500 diluted).Predicted band size:45kDa.Observed band size:45,20kDa.

  • Background
    Swiss-Prot Acc.P29466.Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"