Anti-Bcl10 Rabbit antibody

Anti-Bcl10 Rabbit antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Bcl10 Rabbit monoclonal antibody

WB, IHC-P, ICC/IF, IP

Human

IgG

Antigen: Recombinant protein of human Bcl10

Monoclonal

50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]