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Product Name
Anti-Bak Rabbit antibody
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Description
Bak Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC, IP
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Species reactivity
Human
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Alternative names
BAK; CDN1; BCL2L7; BAK-LIKE antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Bak
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/20
ICC/IF: 1/50
FC: 1/20
IP: 1/20
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Validations
Western blot detection of Bak in K562,Hela cell lysates using Bak Rabbit pAb(1:1000 diluted).Predicted band size:23kDa.Observed band size:23kDa.
Immunohistochemistry of Bak in paraffin-embedded Human colon cancer tissue using Bak Rabbit pAb at dilution 1/20
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Background
Swiss-Prot Acc.Q16611.Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"