Anti-ARTS1/ERAP1 Rabbit antibody
ARTS1/ERAP1 Rabbit monoclonal antibody
WB, IHC-P, ICC/IF, FC
Human, Mouse, Rat
ALAP; A-LAP; ARTS1; ERAAP; APPILS; ARTS-1; ERAAP1; PILSAP; PILS-AP antibody
Antigen: A synthetic peptide of human ARTS1
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Western blot detection of ARTS1/ERAP1 in Hela,C6,Jurkat cell lysates using ARTS1/ERAP1 Rabbit mAb(1:500 diluted).Predicted band size:107kDa.Observed band size:107kDa.
Swiss-Prot Acc.Q9NZ08.Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
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