ERAP1 Polyclonal Antibody

Cat.#: 164392

Special Price 290.3 USD

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Product Information

  • Product Name
    ERAP1 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to ERAP1
  • Tested applications
    WB
  • Species reactivity
    Human
  • Alternative names
    ERAP1 antibody; A-LAP antibody; ALAP antibody; APPILS antibody; ARTS-1 antibody; ARTS1 antibody; ERAAP antibody; ERAAP1 antibody; PILS-AP antibody; PILSAP antibody; endoplasmic reticulum aminopeptidase 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic Peptide of human ERAP1
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, pH7.3.
  • Storage instructions
    Store at 4℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
  • Validations

    Western blot - ERAP1 Polyclonal Antibody

    Western blot - ERAP1 Polyclonal Antibody

    Western blot analysis of extracts of Ramos cells, using ERAP1 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.

  • Background
    Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"