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Product Name
Anti-Annexin A2 Rabbit antibody
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Description
Annexin A2 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC
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Species reactivity
Human, Mouse, Rat
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Alternative names
P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Annexin A2
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/20
ICC/IF: 1/50
FC: 1/20
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Validations
Western blot detection of Annexin A2 in C6,3T3,Hela cell lysates using Annexin A2 Rabbit pAb(1:1000 diluted).Predicted band size:39kDa.Observed band size:38kDa.
Immunocytochemistry of Annexin A2(green) in Hela cells using Annexin A2 Rabbit pAb at dilution 1/50, and DAPI(blue)
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Background
Swiss-Prot Acc.P07355.Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"