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Product Name
Rat CD98/SLC3A2 (Fc Tag) recombinant protein
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Description
Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.
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Protein name
4F2 cell-surface antigen heavy chain
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Protein short names
MGP-2HC; LY10; 4T2HC; CD98HC; SLC3A2; LY-10; AI314110; CD98; 4F2HC; NACAE; LY-M10; 4F2; MDU1
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Uniprot ID
Q794F9
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Gene Name
Slc3a2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat SLC3A2 (Q794F9) (Ala100-Ala527) was expressed with the Fc region of human IgG1 at the N-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat SLC3A2 comprises 688 amino acids and has a predicted molecular mass of 75.8 kDa.
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Purity
> (75.5+21.3) % as determined by SDS-PAGE
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Validations
Rat SLC3A2 / CD98 Protein (Fc Tag)
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