Mouse CD98/SLC3A2 (His Tag) recombinant protein

Mouse CD98/SLC3A2 (His Tag) recombinant protein

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• Material Safety Data Sheets (MSDS)

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.

4F2 cell-surface antigen heavy chain

4F2HC; 4F2; LY10; 4T2HC; CD98HC; AI314110; LY-10; CD98; NACAE; LY-M10; MDU1; MGP-2HC; SLC3A2

P10852

Slc3a2; Mdu1

Human Cells

A DNA sequence encoding the extracellular domain of mouse SLC3A2 (NP_001154885.1) (Ala 139-Ala 565) was fused with a polyhistidine tag at the N-terminus.

Mouse

The secreted recombinant mouse SLC3A2 comprises 446 amino acids and predicts a molecular mass of 49.2 kDa. As a result of glycosylation, the apparent molecular mass of mouse SLC3A2 is approximately 60-70 kDa in SDS-PAGE under reducing conditions.

> 98 % as determined by SDS-PAGE