Anti-CD98/SLC3A2 antibody

Anti-CD98/SLC3A2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to CD98/SLC3A2

ELISA, WB, IHC-P, IP

Human CD98 / SLC3A2

4F2 antibody; CD98 antibody; MDU1 antibody; 4F2HC antibody; 4T2HC antibody; NACAE antibody; CD98HC antibody; 4F2 antibody; Cd98 antibody; Ly10 antibody; Mdu1 antibody; 4F2HC antibody; Ly-10 antibody; NACAE antibody; Ly-m10 antibody; Mgp-2hc antibody; AI314110 antibody; AI314110 antibody; MDU1 antibody; NACAE antibody; NACAE antibody; Slc3a2 antibody; SLC3A2 antibody; 4F2 antibody; 4F2 antibody; 4F2HC antibody; 4F2HC antibody; 4T2HC antibody; Cd98 antibody; CD98 antibody; CD98HC antibody; Ly10 antibody; Ly-10 antibody; Ly-m10 antibody; Mdu1 antibody; Mgp-2hc antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human CD98 / SLC3A2 (rh CD98 / SLC3A2; P08195-1; Arg 206-Ala 630). CD98 / SLC3A2 specific IgG was purified by Human CD98 / SLC3A2 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.

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