ZNF238 antibody

ZNF238 antibody

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ZNF238 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, mouse heart tissue, mouse kidney tissue. Positive IP detected in mouse cerebellum tissue. Positive IHC detected in mouse brain tissue. Observed molecular weight by Western-blot: 48 kDa

ELISA, WB, IP, IHC

Human,Mouse,Rat; other species not tested.

58 kDa repressor protein antibody; C2H2 171 antibody; RP58 antibody; TAZ 1 antibody; TAZ1 antibody; Transcriptional repressor RP58 antibody; ZBTB18 antibody; ZFP238 antibody; zinc finger protein 238 antibody; Zinc finger protein C2H2 171 antibody; ZNF238 antibody

Rabbit IgG

This antibody was obtained by immunization of ZNF238 recombinant protein (Accession Number: NM_205768). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

ZNF238 is a member of the BTB/POZ-ZF protein family, which involve in development and cancer formation, for example BCL-6, PLZF, and HIC-1. It's a transcriptional repressor involve in myogenesis and brain development. By directly repressing the expression of two skeletal myogenesis inhibitors, ID2 and ID3, ZNF238 plays a key role in myogenesis. It can control cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Besides, ZNF238 involves in the organization of nuclear chromosomes, for its specific binding to the consensus DNA sequence that contains the E box core, and recruiting chromatin remodeling multiportein complex. ZNF238 proteins has apparent molecular masses of 60 and 48 kD. Specific binding is found for a 60-kDa band which corresponds to the full length of RP58 protein. In addition, a 48-kDa band, thought to be the truncated form 2 is detected (PMID: 9756912).

• Heng JI, Qu Z, Ohtaka-Maruyama C. The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development. Cerebral cortex (New York, N.Y. : 1991). 25(3):806-16. 2015.