ZFP36 antibody

ZFP36 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ZFP36 Rabbit Polyclonal antibody. Positive WB detected in mouse lung tissue, A549 cells. Positive IF detected in HepG2 cells. Positive IHC detected in human breast cancer tissue, human bladder tissue. Observed molecular weight by Western-blot: 40-45 kDa

ELISA, WB, IF, IHC

Human,Mouse,Rat; other species not tested.

G0S24 antibody; GOS24 antibody; NUP475 antibody; Protein TIS11A antibody; RNF162A antibody; TIS11 antibody; TIS11A antibody; Tristetraproline antibody; TTP antibody; Zfp 36 antibody; ZFP36 antibody; Zinc finger protein 36 homolog antibody

Rabbit IgG

This antibody was obtained by immunization of ZFP36 recombinant protein (Accession Number: NM_003407). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The expression of many cytokines is regulated post-transcriptionally by factors that modulate mRNA transport, translation, and stability. Much of this regulation occurs by the binding and stabilizing, or destabilizing, of cytokine mRNAs by proteins that recognize adenosine and uridine-rich elements (AREs) in untranslated regions of target transcripts. Zfp36 is a mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. It was demonstrated to physically interact with the p65 subunit of nuclear factor-κB leading to decreased nuclear import and diminished transcriptional activation mediated by nuclear factor-κB. It acted by specifically binding ARE-containing mRNAs and promoting their degradation, and has a crucial role in the post-transcriptional regulation of tumor necrosis factor (TNF).

• Tan FE, Elowitz MB. Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase. Proceedings of the National Academy of Sciences of the United States of America. 111(17):E1740-8. 2014.