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Product Name
Human VWF (His Tag) recombinant protein
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Description
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
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Protein name
von Willebrand factor
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Protein short names
6820430P06RIK; VWF; VWD; F8VWF; B130011O06RIK; AI551257; C630030D09
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Uniprot ID
P04275
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Gene Name
VWF; F8VWF
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Source/Expression Host
CHO Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the pro form of human von Willebrand factor (NP_000543.2) (Met 1-Lys 2813) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The secreted recombinant human vWF consists of 2802 amino acids after removal of the signal peptide and has a predicted molecular mass of 308 kDa. Purified rhvWf exists as both the pro form with the pro peptide (307 kDa) and the mature form (226 kDa), which migrates as doublets with apparent molecular mass of 260 and 350 kDa respectively in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 75 % as determined by SDS-PAGE
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Validations
Human vWF Protein (His Tag) SDS-PAGE
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