VEGF Receptor 2 antibody

Cat.#: 116736

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Product Information

  • Product Name
    VEGF Receptor 2 antibody
  • Documents
  • Description
    VEGF Receptor 2 Rabbit Polyclonal antibody. Positive WB detected in human placenta tissue, mouse heart tissue. Positive IHC detected in human oesophagus cancer tissue, human colon cancer tissue, human lung cancer tissue. Observed molecular weight by Western-blot: 200 kDa
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    CD309 antibody; Fetal liver kinase 1 antibody; FLK 1 antibody; FLK1 antibody; KDR antibody; Kinase insert domain receptor antibody; VEGF Receptor 2 antibody; VEGFR antibody; VEGFR 2 antibody; VEGFR2 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of VEGF Receptor 2 recombinant protein (Accession Number: NM_002253). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:50-1:500

  • Validations

    human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:116736(KDR Antibody) at dilution of 1:600

    human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:116736(KDR Antibody) at dilution of 1:600

    Immunohistochemistry of paraffin-embedded human oesophagus cancer tissue slide using Catalog No:116736(KDR Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human oesophagus cancer tissue slide using Catalog No:116736(KDR Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human oesophagus cancer tissue slide using Catalog No:116736(KDR Antibody) at dilution of 1:200 (under 40x lens).

    Immunohistochemistry of paraffin-embedded human oesophagus cancer tissue slide using Catalog No:116736(KDR Antibody) at dilution of 1:200 (under 40x lens).

  • Background
    KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"