USP1 antibody

USP1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

USP1 Mouse Monoclonal antibody. Positive WB detected in Hepg2 cells. Positive IHC detected in human cervical cancer tissue. Observed molecular weight by Western-blot: 100kD

ELISA, WB, IHC

Human; other species not tested.

Deubiquitinating enzyme 1 antibody; hUBP antibody; ubiquitin specific peptidase 1 antibody; Ubiquitin thiolesterase 1 antibody; UBP antibody; USP1 antibody

Mouse IgG2a

This antibody was obtained by immunization of USP1 recombinant protein (Accession Number: NM_001017416). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

USP1(Ubiquitin carboxyl-terminal hydrolase 1) is a negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2.It is Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA.This protein, which consists of 785 amino acids with a deduced molecular mass of 88.2 kDa, possesses His and Cys domains that are highly conserved in all members of the ubiquitin-specific processing (UBP) family of proteases(PMID:9806842). The USP1 enzyme can undergo autocleavage, resulting in a 100 kDa N-terminal fragment and a 14 kDa C-terminal fragment(PMID:18082604).