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Product Name
UNG antibody
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Description
UNG Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue. Positive WB detected in human testis tissue. Observed molecular weight by Western-blot: 28kd,34-40kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DGU antibody; DKFZp781L1143 antibody; HIGM4 antibody; UDG antibody; UNG antibody; UNG1 antibody; UNG15 antibody; UNG2 antibody; uracil DNA glycosylase antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of UNG recombinant protein (Accession Number: NM_003362). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:116620(UNG antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:116620(UNG Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:116620(UNG Antibody) at dilution of 1:50 (under 40x lens)
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Background
UNG(Uracil-DNA glycosylase) removes uracil in DNA resulting from deamination of cytosine or replicative incorporation of dUMP instead of dTMP. Thus, UNG plays a role in suppressing GC-to-AT transition mutations.The UNG gene encodes 2 isoforms that are individually targeted to the mitochondria and the nucleus(PMID:12369930).Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5).
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