UNG antibody

Cat.#: 116620

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Product Information

  • Product Name
    UNG antibody
  • Documents
  • Description
    UNG Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue. Positive WB detected in human testis tissue. Observed molecular weight by Western-blot: 28kd,34-40kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    DGU antibody; DKFZp781L1143 antibody; HIGM4 antibody; UDG antibody; UNG antibody; UNG1 antibody; UNG15 antibody; UNG2 antibody; uracil DNA glycosylase antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of UNG recombinant protein (Accession Number: NM_003362). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    human testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:116620(UNG antibody) at dilution of 1:300

    human testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:116620(UNG antibody) at dilution of 1:300

    Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:116620(UNG Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:116620(UNG Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:116620(UNG Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:116620(UNG Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    UNG(Uracil-DNA glycosylase) removes uracil in DNA resulting from deamination of cytosine or replicative incorporation of dUMP instead of dTMP. Thus, UNG plays a role in suppressing GC-to-AT transition mutations.The UNG gene encodes 2 isoforms that are individually targeted to the mitochondria and the nucleus(PMID:12369930).Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"