Cynomolgus OX-40L / TNFSF4 / CD252 (Fc Tag) recombinant protein

Cynomolgus OX-40L / TNFSF4 / CD252 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

Uncharacterized protein

OX-40L; GLYCOPROTEIN GP34; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 4; CD134 LIGAND; TNFSF4; CD134L; TAX TRANSCRIPTIONALLY-ACTIVATED GLYCOPROTEIN 1; ATH-1; TXGP1L; CD252; OX4OL; GP34; OX40 ANTIGEN LIGAND; ATH1; MEMBER 4; TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY; OX40L; TAX-TRANSCRIPTIONALLY ACTIVATED GLYCOPROTEIN 1 (34KD); TXGP1

F7FL80

TNFSF4; EGK_01976

Human Cells

A DNA sequence encoding the cynomolgus TNFSF4 (F7FL80) (Gln51-Leu183) was expressed with the Fc region of mouse IgG1 at the N-terminus.

Cynomolgus

The recombinant cynomolgus TNFSF4 is a disulfide-linked homodimer. The reduced monomer comprises 369 amino acids and has a calculated molecular mass of 42 KDa.The apparent molecular mass of it is approximately 48 KDa respectively in SDS-PAGE.

> 85 % as determined by SDS-PAGE

Immobilized Cynomolgus mFc-TNFSF4 at 10 μg/ml (100 μl/well) can bind human TNFRSF4-Fch (Cat:503893), The EC₅₀ of human TNFRSF4-Fch (Cat:503893) is 0.23-0.55 μg/ml.