Human OX-40L / TNFSF4 / CD252 (Fc Tag) recombinant protein

Human OX-40L / TNFSF4 / CD252 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

Tumor necrosis factor (Ligand) superfamily, member 4 (Tax-transcriptionally activated glycoprotein 1, 34kDa), isoform CRA_a

ATH1; OX40 ANTIGEN LIGAND; TAX-TRANSCRIPTIONALLY ACTIVATED GLYCOPROTEIN 1 (34KD); TXGP1; MEMBER 4; TUMOR NECROSIS FACTOR (LIGAND) SUPERFAMILY; OX40L; GLYCOPROTEIN GP34; CD134 LIGAND; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 4; TNFSF4; CD134L; OX-40L; CD252; OX4OL; GP34; TAX TRANSCRIPTIONALLY-ACTIVATED GLYCOPROTEIN 1; ATH-1; TXGP1L

P23510

TNFSF4; hCG_37644

Human Cells

A DNA sequence encoding the human TNFSF4 (NP_003317.1) (Gln51-Leu183) was expressed with the Fc region of mouse IgG1 at the N-terminus.

Human

The recombinant human TNFSF4 consists of 369 amino acids and predicts a molecular mass of 42.1 kDa.

> 90 % as determined by SDS-PAGE.