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Product Name
Human UDP galactose-4'-epimerase / GALE (His Tag) recombinant protein
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Description
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
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Protein name
UDP-glucose 4-epimerase
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Protein short names
2310002A12RIK; SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY 1E; GALACTOSE-4-EPIMERASE; UDP GALACTOSE-4'-EPIMERASE; MEMBER 1; GALACTOWALDENASE; RP5-886K2.6; UDP-GLUCOSE 4-EPIMERASE; UDP-GALACTOSE 4-EPIMERASE; RP23-161N17.8; UDP; AI323962; GALE; SDR1E1; UDP-GALACTOSE-4-EPIMERASE
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Uniprot ID
Q14376
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Gene Name
GALE
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human GALE (Q14376) (Met1-Ala348) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human GALE consists of 363 amino acids and predicts a molecular mass of 40.1 KDa. It migrates as an approximately 36 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human GALE / UDP galactose-4-epimerase Protein (His Tag) SDS-PAGE
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