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Product Name
Anti-UDP galactose-4'-epimerase / GALE antibody
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Description
Rabbit polyclonal to UDP galactose-4'-epimerase / GALE
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Tested applications
ELISA, IHC-P
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Species reactivity
Human UDP galactose-4'-epimerase / GALE
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Alternative names
UDP-galactose-4-epimerase antibody; GALE antibody; RP5-886K2.6 antibody; SDR1E1 antibody; UDP galactose-4'-epimerase antibody; UDP-glucose 4-epimerase antibody; galactose-4-epimerase antibody; UDP antibody; galactowaldenase antibody; short chain dehydrogenase/reductase family 1E antibody; member 1 antibody; galactose-4-epimerase antibody; UDP antibody; Gale antibody; RP23-161N17.8 antibody; 2310002A12Rik antibody; AI323962 antibody; UDP-galactose 4-epimerase antibody; UDP-glucose 4-epimerase antibody; galactowaldenase antibody; SDR1E1 antibody; AI323962 antibody; 2310002A12Rik antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human UDP galactose-4'-epimerase / GALE (rh UDP galactose-4'-epimerase / GALE; Q14376; Met1-Ala348). UDP galactose-4'-epimerase / GALE specific IgG was purified by Human UDP galactose-4'-epimerase / GALE affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human UDP galactose-4'-epimerase / GALE. The detection limit for Human UDP galactose-4'-epimerase / GALE is < 0.039 ng/well.
IHC-P: 0.1-2 μg/ml
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Validations
UDP galactose-4'-epimerase / GALE Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of human GALE in human lung cancer with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
UDP galactose-4'-epimerase / GALE Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of human GALE in human placenta with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
UDP galactose-4'-epimerase / GALE Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of human GALE in human prostatic carcinoma with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
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Background
UDP galactose-4'-epimerase, also known as GALE, enables the body to process a simple sugar called galactose, which is present in small amounts in many foods. Galactose is primarily part of a larger sugar called lactose, which is found in all dairy products and many baby formulas. UDP galactose-4'-epimerase catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. Defects in GALE causes epimerase-deficiency galactosemia (EDG), also known as galactosemia type 3. Clinical features include early-onset cataracts, liver damage, deafness and mental retardation.
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References
- Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
- Lee KA. et al., 2011,. J Biol Chem. 286 (48): 41530-8.
- McCorvie TJ. et al., 2012, Biochim Biophys Acta. 1822 (10): 1516-26.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"