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Product Name
Human UBE2T/HSPC150 (His Tag) recombinant protein
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Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
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Protein name
Ubiquitin-conjugating enzyme E2 T
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Protein short names
PIG50; HSPC150; C80607; 2700084L22RIK
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Uniprot ID
Q9NPD8
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Gene Name
UBE2T; HSPC150; PIG50
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human UBE2T (Q9NPD8) (Met1-Val197) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human UBE2T consists of 207 amino acids and has a calculated molecular mass of 23.9 kDa.
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Purity
> 90 % as determined by SDS-PAGE.
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Validations
Human UBE2T Protein (His Tag)
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