Ubiquilin 1 antibody

Ubiquilin 1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Ubiquilin 1 Rabbit Polyclonal antibody. Positive WB detected in rat brain tissue, L02 cells, rat heart tissue, rat liver tissue, Transfected HEK-293 cells. Positive IF detected in L02 cells. Observed molecular weight by Western-blot: 62-71 kDa

ELISA, WB, IF

Human, Rat; other species not tested.

DA41 antibody; DSK2 antibody; FLJ90054 antibody; hPLIC 1 antibody; PLIC 1 antibody; PLIC1 antibody; ubiquilin 1 antibody; UBQLN1 antibody; XDRP1 antibody

Rabbit IgG

This antibody was obtained by immunization of Ubiquilin 1 recombinant protein (Accession Number: NM_053067). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP (PMID: 21852239). This antibody detects 70kD band of UBQLN1.