UBIAD1 Polyclonal Antibody

Cat.#: 161620

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Product Information

  • Product Name
    UBIAD1 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to UBIAD1
  • Tested applications
    WB, IHC
  • Species reactivity
    Human, Mouse
  • Alternative names
    UBIAD1 antibody; SCCD antibody; TERE1 antibody; UbiA prenyltransferase domain containing 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human UBIAD1 (NP_037451.1).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IHC 1:50 - 1:200
  • Validations

    Western blot - UBIAD1 Polyclonal Antibody

    Western blot - UBIAD1 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using UBIAD1 antibody at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 60s.

    Immunohistochemistry - UBIAD1 Polyclonal Antibody

    Immunohistochemistry - UBIAD1 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded human stomach using UBIAD1 antibody at dilution of 1:100 (40x lens).

  • Background
    Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"