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Product Name
Mouse PTPN6 (aa 207-597, His & GST Tag) recombinant protein
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Description
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
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Protein name
Tyrosine-protein phosphatase non-receptor type 6
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Protein short names
HEMOPOIETIC CELL PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; ME; PTPN6; PROTEIN-TYROSINE PHOSPHATASE 1C; HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE; PTP-1C; SHP1; HCPH; SH-PTP1; NON-RECEPTOR TYPE 6; 70Z-SHP; HEMATOPOIETIC CELL PHOSPHATASE; MOTHEATEN; PTPTY-42; PTP1C; HCP; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6; SHP-1; HPTP1C; SHP-1L; PROTEIN-TYROSINE PHOSPHATASE SHP-1
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Uniprot ID
P29351
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Gene Name
Ptpn6; Hcp; Hcph; Ptp1C
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse PTPN6 (P29351-2) (Ala207-Lys597) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse PTPN6/GST chimera consists of 628 amino acids and has a calculated molecular mass of 72.7 kDa. The recombinant protein migrates as an approximately 63 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Activity
Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988998 phosphopeptide substrate, R&D Systems, Catalog # ES006.
The specific activity is > 4 μmoles/min/μg. -
Validations
Mouse PTPN6 Protein (aa 207-597, His & GST Tag) SDS-PAGE
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