Mouse PTPN6 (aa 207-597, His & GST Tag) recombinant protein

Cat.#: 502622

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Product Information

  • Product Name
    Mouse PTPN6 (aa 207-597, His & GST Tag) recombinant protein
  • Documents
  • Description
    Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
  • Protein name
    Tyrosine-protein phosphatase non-receptor type 6
  • Protein short names
    HEMOPOIETIC CELL PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; ME; PTPN6; PROTEIN-TYROSINE PHOSPHATASE 1C; HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE; PTP-1C; SHP1; HCPH; SH-PTP1; NON-RECEPTOR TYPE 6; 70Z-SHP; HEMATOPOIETIC CELL PHOSPHATASE; MOTHEATEN; PTPTY-42; PTP1C; HCP; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6; SHP-1; HPTP1C; SHP-1L; PROTEIN-TYROSINE PHOSPHATASE SHP-1
  • Uniprot ID
    P29351
  • Gene Name
    Ptpn6; Hcp; Hcph; Ptp1C
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse PTPN6 (P29351-2) (Ala207-Lys597) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse PTPN6/GST chimera consists of 628 amino acids and has a calculated molecular mass of 72.7 kDa. The recombinant protein migrates as an approximately 63 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988998 phosphopeptide substrate, R&D Systems, Catalog # ES006.
    The specific activity is > 4 μmoles/min/μg.
  • Validations

    Mouse PTPN6 Protein (aa 207-597, His & GST Tag) SDS-PAGE

    Mouse PTPN6 Protein (aa 207-597, His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"