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Product Name
TXNL6 antibody
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Description
TXNL6 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, HeLa cells. Positive IHC detected in human breast cancer tissue. Observed molecular weight by Western-blot: 26-28kd
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
nucleoredoxin like 1 antibody; Nucleoredoxin like protein 1 antibody; NXNL1 antibody; RDCVF antibody; Thioredoxin like protein 6 antibody; TXNL6 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TXNL6 recombinant protein (Accession Number: NM_138454). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:116457(TXNL6 antibody) at dilution of 1:800
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:116457(TXNL6 antibody) at dilution of 1:100 (under 10x lens)
IP Result of anti-TXNL6 (IP:Catalog No:116457, 4ug; Detection:Catalog No:116457 1:500) with mouse brain tissue lysate 4000ug.
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Background
TXNL6, also named as NXNL1, belongs to the nucleoredoxin family. It may play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods. TXNL6 is a Novel Oxidative Stress-Induced Reducing System for Methionine Sulfoxide Reductase A Repair of a-Crystallin and Cytochrome C in the Eye Lens. It serve as a reducing system for MsrA repair of the essential lens chaperone a-crystallin/sHSP and mitochondrial cytochrome c. TXNL6 is induced at high levels in human lens epithelial cells exposed to H2O2-induced oxidative stress.(PMID:21079812)
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References
- Brennan LA, Lee W, Kantorow M. TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens. PloS one. 5(11):e15421. 2010.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"