-
Product Name
Human EDAR/Ectodysplasin A Receptor (His Tag) recombinant protein
- Documents
-
Description
Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers, thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
-
Protein name
Tumor necrosis factor receptor superfamily member EDAR
-
Protein short names
EDAR; ED3; DL; EDA-A1R; HRM1; ED1R; EDA1R; ECTD10B; FLJ94390; EDA3; ED5; ECTD10A
-
Uniprot ID
Q9UNE0
-
Gene Name
EDAR; DL
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the human EDAR (NP_071731.1) extracellular domain (Met 1-Ile 189) was fused with a polyhistidine tag at the C-terminus.
-
Protein Species
Human
-
Molecular weight
The secreted recombinant human EDAR consists of 174 amino acids and has a predicted molecular mass of 19 kDa. The apparent molecular mass of the protein is approximately 30-40 kDa in SDS-PAGE under reducing conditions.
-
Purity
> 96 % as determined by SDS-PAGE
-
Validations
Human EDAR / DL Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"