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Product Name
TTBK2 Polyclonal Antibody
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Description
Polyclonal antibody to TTBK2
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Tested applications
IF
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Species reactivity
Human
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Alternative names
TTBK2 antibody; SCA11 antibody; TTBK antibody; tau-tubulin kinase 2 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1185-1244 of human TTBK2 (NP_775771.3).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
IF 1:50 - 1:200
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Validations
Immunofluorescence - TTBK2 Polyclonal Antibody
Immunofluorescence analysis of A549 cells using TTBK2 antibody . Blue: DAPI for nuclear staining.
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Background
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"