Human Tryptophan Hydroxylase 1/TPH1 (His Tag) recombinant protein

Human Tryptophan Hydroxylase 1/TPH1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme which belongs to the biopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains one ACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. TPH1 expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells.The tryptophan hydroxylase 1 (TPH1) gene is also reported to be associated with suicidal behavior. Polymorphisms of TPH1 may assist in identifying a subgroup of mood disorder patients that is at higher risk for suicidal behavior.

Tryptophan 5-hydroxylase 1

TPH; MGC119994; TPRH; TRPH; TPH1; TRYPTOPHAN HYDROXYLASE 1

P17752

TPH1; TPH; TPRH; TRPH

E. coli

A DNA sequence encoding the human TPH1 (P17752-1) (Ile 2-Ile 444) was expressed, with a polyhistide tag at the N-terminus.

Human

The recombinant human TPH1 consisting of 458 amino acids and has a calculated molecular mass of 52.7 kDa. It migrates as an approximately 48 kDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE